W E B A N A L Y T E S Biomedical Page
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| New links: | Biochemistry and Molecular Biology | Approved Drug ProductsFDA |
| Everything added to food in the US | Biotechnology Applications | Enzyme Technology-Introduction to |
Biochemistry and Biotechnology Back to Top
Online Books
- www.webanalytes.com/books.htm Covers Free Online Books Biochemistry, Enzyme Kinetics & Biotechnology and Biosensors
Enzymes and Cofactors
- IUBMB Biochemical & Organic Nomenclature, Symbols & Terminology (including Enzymes) or
- IUPAC Biochemical & Organic Nomenclature, Symbols and Terminology
- Enzyme-catalyzed Reactions (Thermodynamics of); NIST
- Enzymes A well-structured database based on the classification of EC Nomenclature (EC 1 – EC 6)
- LIGAND Database for enzymes, compounds, and reactions
- ExPasy.ENZYME Enzyme nomenclature database; Finding by EC Number; Search box; or by clicking links- class, name or part of name, cofactor; search results include cross references to other Enzyme databases and links to PubMed research abstracts on the enzyme
- Worthington Enzyme Manual Enzymes and related biochemicals (Index) ; for clinical/food analysis labs and biomedical research; includes basic literature information, enzymatic assay procedures and extensive literature references on each
- Enzyme Cofactors The reactions of Cofactors (and soluble vitamins are either converted to cofactors or used directly as a cofactor, e.g. vitamin C) are explained in this course material
- Online Books on Enzymes in Electronic Library I e.g. “Enzyme Biochemistry” and “Enzyme Kinetics”, “On-Line Biology Book”)
- The Enzyme Explorer A very well organised database with indexes for applications, enzyme classes, inhibitors, substrates, lectins, and enzyme co-factors; Sigma-Aldrich
Enzymatic/Biochemical Pathways
- Metabolic Pathways of Biochemistry
- Metabolic Pathways ExPASy Proteomics Server of the Swiss Institute of Bioinformatics. An electronic index allows quick localization of any metabolite or enzyme on the chart; Roche Applied Science
- Pathways Biochemical Cycles; University of Akron
- The Main Metabolic Pathways on the Internet Pieter van Santen
Assays and Protocols
- Biochemical Tests, Media, Techniques Qualitative Test Methods by action of chemicals on Microorganisms; University of Texas – Houston Medical School
- Biochemistry Techniques See lectures: Lec1, Lec2, Lec3, Lec4, Lec5, Lec6
- Calzyme Product Catalogue for Biochemicals and Enzymes with links that include introduction and assay Methods
- Laboratory Protocols 15/03/04
- PCR Application Manual, 2nd ed. (in Technical Manuals of Roche-applied-science) Applications include detection of Human Chromosomes, and non-radioactive labeling are discussed
- Protein and Activity Assay Biochemistry Experimental Techniques
- Powerpoint presentation cited in reference: Anderson D, Baker L, Chiu A, Compitello G, Galvin M. “Development of a Rapid Microplate Assay for Threonine Dehydrogenase,” ACS Rochester section, 41st Undergraduate Research Symposium, Rochester, NY, April 27, 1996
- Protein Assay Resource (Brad Olson’s)18/05/04
- R-Biopharm Online Includes Enzymatic Bioanalysis, Feed and Food Analysis and Clinical Diagnostics
- Newsletter Diagnostic Today (PDF) Beckman Coulter
- Online Lecture
Biotechnology Topics -Specific and General
- Advanced Analytical Biochemistry Topic and Notes, Lab Notes, Questions; Ngee Ann Polytechnic, Singapore
- Applied Biocatalysis (7 powerpoint presentations) A Course in Wageningen University, The Netherlands
Biochemical Separation Methods A Course in Wageningen University, The Netherlands - Chitosan and Chitosan Oligomer from crab shell
- Enzyme Technology-Introduction to Industrial Enzymology, Biosensors, Biotransformations, Protein Engineering, Immobilised Enzymes Applied enzyme kinetics; e.g.
- Immobilised Enzymes Immobilisation, Kinetics and Reactors; The University of Reading, UK
- IONTOSORB Bead Cellulose Derivatives Applications menu: Macroporous Sorbents for Bioseparations, Ion Exchange, Affinity and Dye-Ligand Chromatography, Selective Chelating Sorbents, IMAC and Sorbents for Enzyme Immobilization, see e.g. Iontosorb AV
- LabWork Online Microbiology and Immunology experiments; University of Leicester, UK
- Enzyme Technology Online manual (16 experiments) and examples of student video reports, Enzyme purification, catalysis, assays, immobilisation, cell culture and fermentation; Nam Sun Wang’s Biochemical Engineering Laboratory
- Biotechnology Applications (Pierce Handbooks & Catalogues, new 2003/04) Pierce Biotechnology techniques -over 25 Handbooks, guides and posters (PDF) Examples: Biotechnology handbooks for
- Protein Assay, Affinity Purification Western Blot, GC/HPLC updated 24/11/04
- Handbook of Fluorescent Probes and Research Products A 24-chapter Handbook for all applications of fluorogenic detections and quantitative reactions ranging from simple ion detections to protein and immunoassays (Chapter content, list of Tables and Figures Molecular Probes, Inc.
- Purification of Lactobacillus amylovorus alpha amylase NgeeAnn Polytechnic, Singapore
- Handbook of Sample Preparation and Handling Biotechnology section; SPEX CertiPrep
- Water Structure and Behavior A unique and a great web site for the unique and universal solvent -of immense interest to any chemist -with sections that exhibit it’s huge significance in biochemical systems
Industrial Enzymes and Biochemicals
- Applications of Enzyme Technology in the Textile Industry An open distance learning text produced by the Nottingham Trent University 25/05/04
- Industrial Uses of Enzymes (Word document)
Clinical & Forensic Chemistry Back to Top
- Lecture Notes and Tools
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Biochemistry and Molecular Biology Class notes, Chapter questions and includes topics related to: water, amino acids, enzymes and enzyme kinetics; Minnesota State Univ.13/11/04
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Fatty Acid Metabolism -Advanced Analytical Biochemistry Course; NgeeAnn Polytechnic, Singapore
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Pharmaceutical and Biomedical Analysis Lecture note (187 pp) and exams (PDF files); PHCEU 431 Duquesne University School of Pharmacy, Pittsburg, PA
- Drug Monitor e.g.
- Acid-Base Disorders
- Clinical Tools Equations for all occasions; e.g. Acid-Base tools and Creanine clearance
- Magnesium Clinical Significance
- Four Most Important Equations in Clinical Practice
- Forensic Analytical Chemistry (Chem 622, Fall 2002) Syllabus, Lecture topics, Bibliography and Links to Forensic Analytical Chemistry Resources; University of South Carolina
- The Immunology Book Case - Educational information on Antibody Structure, Antibody Recognition
- Clinical Analyte Unit Conversion Follow steps in page to convert mg/L to umol/L
- Online Clinical Calculator
- SI Units for Clinical Data in Dictionary of Units of Measurements (A-Z)
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- Presentations
- Dr Roger Bertholf’s Power Point Lectures 18 downloadable Laboratory medicine lectures: Clinical and Forensic Analysis . A very lively site from one of the many known Bertholfs’ Websites
- Hair Analysis and Forensic Toxicology +, Power point Presentations; Murdoch University Forensic Science
- Introduction to Electrophoresis Slides 1-33; Frontiers in Biosience
- ELISA Activity (Introduction to) and Western Blot Activity illustrates HIV detection; HIV and AIDS Tutorial; The Biology Project; U of Arizona
- Immunoassay Animations Five examples from Radioimmunoassay, ELISA, Sandwich and Competitive; University of Glasgow
- Interactive Biochemistry Amino acid Titration and Protein Structure, Enzyme Kinetics, Enzyme Mechanism; University of Virginia
- Understanding Gene Testing Online lecture
Assays and Protocols
- Application Notes: Spectrophotometry Biomedical applications for analytes determinations including enzymatic methods; Biochrom Ltd, UK
- Blood Chemistry Definitions This is more than a definition; well organised reference to the Chemistry of Blood CellMate Wellness SystemsTM
- Biochemical Calculations for clinical chemistry; SydPath: St Vincent’s Hospital, Sydney, Australia
- Detection and Analysis of Drugs of Forensic Interest Review (1992 – 2001); A Literature Review
- Specimen Handling Database for clinical chemistry; SydPath: St Vincent’s Hospital, Sydney, Australia
- Creatinine and Protein Assays on the same samples in a single plate
- Use of Ion-Selective Electrodes for Blood-Electrolyte Analysis. Recommendations for Nomenclature, Definitions and Conventions; IUPAC
- Introduction to Laboratory Tests The Complete Blood Count (CBC), Urinalysis, Serum Electrolytes, Liver and Billary Tract Tests; with reference ranges and implications under sub- or abnormal concentration levels
- Lab Tests Online Select from Test menu, click “Test Sample” and the “Test”; The American Association for Clinical Chemistry
- Malaria an Online Resource Including Laboratory Diagnosis
- HIV Testing
- HIV Testing A 9-page site Teachers’ resource; Museum of Science and Industry
- Human Immunodeficiency Virus With literature references cross-referenced hyperlinks; useful for researchers; ARUP Guide for Clinical Lab Testing
- FDA HIV Testing
- HIV Testing FAQ
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Diagnostic Biosensors and Immunoassays
- Affinity Sensors Immunoaffinity experiments: Protocols, analytical applications in PDF files; List of Journal Articles 2001-1993; Labsystems, Inc.Biosensors and Other Medical and Environmental Probes
- BIOSENSORS: PAST, PRESENT AND FUTURE Anthony P F Turner; Cranfield University, UK
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Chemical and Biochemical Sensors and Enzyme- and Immunoassays Free sample articles from Ullmann’s Encyclopedia of Industrial Chemistry 2003
Databases
- Reference Intervals
- Clinical Values Very diverse -Reference Intervals in physiological fluids (urine, whole blood, serum plasma, sweat—-) and stool plus Reference materials, buffers and units
- ARUP’s Laboratory Clinical Testing A-Z Guidelines to methods: clinical significance and reference intervals in human body fluids e.g. plasma amino acids; Hepatitis A Virus (HAV); Trace elements; Database Search e.g. Mercury; HIV, Enzyme immunoassay
- Blood Test Results -Normal Ranges with What does my blood test mean?
- Common Medical Tests and Reference
- G.R.I. Clinical Biochemistry Handbook Comprehensive
- MLabs Handbook, Test Directory Search database e.g. Glucose; University of Michigan
- Normal Laboratory Values A-z index, Table 296-2 , Chapter 296; Merck Manual
- Normal Reference Range Table
- Pediatric Reference Ranges
- Trace Elements Index Clinical Significance and Reference Ranges for Trace Elements in humans ARUP Laboratories
Drugs/Pharmaceuticals Back to Top
Drug Databases
- Structure & Activity
- Approved Drug Products -Electronic Orange Book with Therapeutic Equivalence Evaluations Current through February 2005 2/04/05
- AIDSDrugs Structures Substances listed in the US National Library of Medicine’s (NLM) AIDSDRUGS file with viewable structures ( see chemical Structure Viewers)
- Chemicals with Pharmaceutical Activity A database (A-Z) of 3D structures for 400 molecules; Oxford University
- Drug Database Alphabetical order and Drug Activity Classification; Jinno Laboratory, Toyohashi University of Technology
- 3D Pharmaceutical Structures Databases of molecules viewed, rotated, and animated with Chime, the Chemscape plug-in by MDL; Tokyo University of Pharmacy and Life Science,
- Pharmacology Central A Virtual Pharmacopeia with Structure Databases, in categories of Active Principles
- Therapeutic Ranges, Lethal Doses and Testing
- Guide for the interpretation of analytical toxicology …..Refers to interpretation of therapeutic and toxic drug levels in humans in “Guidelines for the interpretation of analytical toxicology results and unit of measurement conversion factor” Annals of Clinical Biochemistry 1998; 35:261-7;
- Toxic Chemicals and their Lethal Dosage (LD) (LD) values for plant natural products: Choose from list (A-Z) and click ”Submit Query” for LD values and Click Chemical’s hyperlink forbiological activities and plant species with highest amount; Dr. Duke’s Phytochemical and Ethnobotanical Databases
- Drug Therapeutic Range Table 296-3 Normal Laboratory Values, Chapter 296; Merck Manual
- Pharmweb Virtual Library has titles:
- A Compendium of Unofficial Methods Rapid Screening of Pharmaceuticals by Thin Layer Chromatography (PDF)
- Rapid Screening of Tuberculosis Pharmaceuticals by Thin Layer Chromatography (PDF)
- CosmetLex Cosmetics Vol 2 – Methods of analysis (PDF); European Union
Drug Development
- Burger’s Medicinal Chemistry and Drug Discovery 4 Free sample Articles
- Inhibitors of HIV Protease: An Introduction to Carbonyl Chemistry Reflects the support of Analytical Methods in understanding Drug Development for AIDS
Prohibited/Regulated/Controlled Substances: Drugs, CWAs .. Back to Top
Drugs of Abuse
- Resources
- Erowid’s Psychoactive Vaults Exceedingly organised drop-down menu database of Psychoactive Chemicals and Substances including Drugs of Abuse and Pharmaceuticals; Erowid’s Project seeks donation of support
- Lists
- Anti-doping: Prohibited list of Substances and Methods (PDF) with Urinary concentrations above which IOC-accredited labs must report findings; World Anti-doping Agency (WADA)
- Prohibited Classes of Substances and Prohibited Methods (PDF); US Anti-doping Agency
- Banned Drug Classes National Collegiate Athletic Association, USA, NCAA Drug-Testing Programs
- Drug Schedules ( US DEA Schedules I-V) Basic or parent chemical and does not describe the salts, isomers and salts of isomers, esters, ethers and derivatives which may also be controlled substances 6/02/04
- Definitions: Section 812 Schedules of controlled substances in DEA Drug Control Act
- Controlled Substances Lists: Yellow = Drugs, Red = Drug Manufacture , Green = Psychotropic substances (PDF files); INCB (International Narcotics Control Board)
- Drug List prohibited prohibited, restricted restricted, permitted, permitted drugs list formulated for Sport in South Africa based on local information infosource.co.za
- Drugs of Abuse Categories and effects; The National Clearinghouse for Alcohol and Drug Information
Note Chemfinder.com may be used to search by chemical in each list (e.g. ephedrine, or its CA Registry No. 299 42-3) to find basic chemical data and information that may also be regulatory
- Assays and Tests (Standards, Research Articles, Reviews, Bibliography, Publications)
- Anti-doping Standards Items under Research and Science for prohibited substances in athletics and sports; (WADA) 31/08/03
- Bulletin on Narcotics Use its Search box or its Indices A-Z (e.g. Subject Index to select e.g. Tests, Testing, Qualitative, Quantitative, Laboratory etc) e.g. of results below (United Nations Office for Drug Control and Crime Prevention (ODCCP)
- Application Notes and Chromatographic Database for Drugs; Agilent Technologies
- Bibliography of Publications Relating to All Aspects of Hair Testing (Preliminary list)
- Erowid’s Drug Testing Vault
- Detection and Analysis of Drugs of Forensic Interest Review (1992 – 2001); A Literature Review, Microgram Journals
- International Journal of Drug Testing
- Testing urine for drugs of abuse Alan H. B. Wu in IVD Technology July/August 2002
Chemical Warfare Agents, CWAs
- Lists
- Chemical Warfare Agents links lists in 4 or 5 CWA categories to a basic data source and TOXNET databases; U.S. National Library of Medicine
- Detection and Monitoring +
- Analytical Methods Development (Slide Presentation) for Chemical Warfare Agents, PCB and other Pollutants
- Biocatalytic Decontamination in Unusual Environments (Slide Presentation) Applications of enzyme to destruction of chemical agents
- Chemical Detection Equipment (CBRNE) Typical detection systems for Chemical Warfare Agents (CWAs) used in Chemical Weapons (CWs); eMedicine, Oct 15 2001, Vol 2, No 10
- Chemical Agent Detector Kit (M256 Series)I
- Impact of Scientific Developments on the Chemical Weapons Convention (Lecture Abstracts): IUPAC Workshop, Bergen, Norway, 30 June-3 July 2002. Pure Appl. Chem. 74(12), 2323-2352, 2002
- Miniature Mass Spectrometers and Mobile GC/MS including Ion Mobility Spectrometers for CWA’s
Food Chemistry Back to Top
Resources
- Analytical Progress and Technical Bulletins Testing information from Medallion Laboratories USA 1/10/04
- Honey Composition, Properties, Applications in Foods and Beverages, Microbiology
Education
- ANALYSIS OF FOOD PRODUCTS; Sampling, Component Analysis, Instrumental Techniques, Textbooks; University of Massachusetts
- FOOD CHEMISTRY Basics of Food Biochemicals (e.g. vitamins) and addititves; ChemSoc (RSC’s Chemistry Network)
- Food Science Courses with more information on the web
- Food Chemistry Lecture and Laboratory Course Ohio U. Food Science & Technology
- Food and Science Utah Education Network
- Food 302 Home : Course Modules Proximate Analysis, Methods for Analysis, Methods for Separation
- Unit operations in Food technology Efficient site with many parameters in drop-down menus that includes Enzyme and Microbial Kinetics, Acid-base Systems and other student tools; Pasquale Petrilli, Department of Food Science, U of Naples
- Food Chemistry and Analyses Power point presentations; Ohio University Food Science & Technology
- Food Chemistry and Preservation; Hong Kong Institute of Education
- Reaction Kinetics of Food Deterioration (PDF); Lecture course rarely available on the Internet; University of Minnesota
- Nutritional Labelling Voluntary and Mandatory, US Nutritional Labelling and Education Act (NLEA)
Tests for Nutritional Labeling Medallion Labs, USA
Databases
- Databases>Foods & Drinks in a new Window
Food Microbiology and Toxins
- Foodborne Pathogenic Microorganisms and Natural Toxins Handbook The Bad Bug Book, Center for Food Safety & Applied Nutrition (The US FDA) based in Washington, D.C detection, decontamination, antidotes and protection against natural toxins/toxic chemicals
- Determination of Mycotoxins-Training Course materials and fact sheet and more; European Mycotoxin Awareness Network
Method Validations and Standard Methods
- see Standards Page>Food, Pharmaceutical and Clinical Methods in a new Window
Additives to Foods (and other Products) Back to Top
Health Guides
- Food Additives Guides
- Food Additives Regulation (Select English, content linked: PDF file); The Swedish National Food Administration
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Chemical Cuisine -Guide to Food Additives from Center for Science in the Public Interest, CSPI , North American non-profit, consumer organisation
Food Additives/related Databases
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JOINT FAO/WHO EXPERT COMMITTEE ON FOOD ADDITIVES (JECFA) http://www.fao.org/es/esn/jecfa/database/cover.htm
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Colours & Dyes Science of Colours & Dyes External to this window
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Color Additives Cosmetics, Foods, Medical Devices and Drugs; US FDA
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Food Additives and Contaminants (PDF) Residues of Veterinary Drugs in Animals and Foods (PDF files); FAO Publications
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Food additives Approved in the European Union, including E numbers with useful links
- Food Additives, E Numbers With more Categories by Properties; UK Additives and Ingredients Association
- Flavors, Oils, Essences Fragrances Perfumery Database: 17 Information indices; A-Z’s (see low left frame) and other Perfume related Databases; The Good Scents Company
- International Nomenclature of Cosmetic Ingredients, Enterprise DG – European Commission; Click Cosmetics>INCI or directly by
